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Science 10 June 1966:
Vol. 152. no. 3728, pp. 1517 - 1519
DOI: 10.1126/science.152.3728.1517
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Articles

Allelic Antigenic Factor Inv(a) of the Light Chains of Human Immunoglobulins: Chemical Basis

C. Baglioni 1, L. Alescio Zonta 1, D. Cioli 1, and A. Carbonara 2

1 International Laboratory of Genetics and Biophysics, C. P. 104, Naples, Italy
2 Institute of Human Genetics, University of Turin, Italy

Twenty-seven Bence Jones proteins of immunological type K show a common set of peptides. One 6f the commnon peptides differs in three of the proteins which are the only ones classified by a serological test as Iav(a+). The difference in the peptide analyzed is caused by a valine-leucine interchange; Inv(a+) proteins have leucine, whereas Inv(a-) proteins have valine in position 189.


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