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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1396 - 1397
DOI: 10.1126/science.152.3727.1396
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Articles

Stimulation of the Proliferation of Cortical Neurons by Prenatal Treatment with Growth Hormone

Stephen Zamenhof 1, Josephine Mosley 1, and Edith Schuller 1

1 Department of Medical Microbiology and Inmnunology, and Department of Biological Chemistry, University of California, Los Angeles

Subcutaneous or intravenous injections daily of purified bovine pituitary growth hormone into pregnant rats from the 7th till the 20th day of pregnancy (total dose 36 mg) resulted in offspring with unchanged body weight but with significant increases in brain weight, brain DNA content, cortical cell density, and ratio of neurons to glia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Maternal Growth Hormone Treatment Increases Placental Diffusion Capacity But Not Fetal or Placental Growth in Sheep.
J. E. Harding, P. C. Evans, and P. D. Gluckman (1997)
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Cell-Cell Signaling in Early Cortical Development.
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Neuroscientist 1, 268-276
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Prolongation of gestation by growth hormone: a confounding factor in the assessment of its prenatal action.
P. Croskerry and G. Smith (1975)
Science 189, 648-650
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Fetal Bin Growth: Selective Action by Growth Hormone.
V. R. Sara, L. Lazarus, M. C. Stuart, and T. King (1974)
Science 186, 446-447
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Prenatal Cerebral Development: Effect of Restricted Diet, Reversal by Growth Hormone.
S. Zamenof, E. van Marthens, and L. Grauel (1971)
Science 174, 954-955
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Brain Enhancement in Tadpoles: Increased DNA Concentration after Somatotrophin or Prolactin.
R. K. Hunt and M. Jacobson (1970)
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DNA (Cell Number) and Protein in Neonatal Brain: Alteration by Maternal Dietary Protein Restriction.
S. Zamenhof, E. Van Marthens, and F. L. Margolis (1968)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)