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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1379 - 1381
DOI: 10.1126/science.152.3727.1379
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Articles

Influenza Virus Purification with the Zonal Ultracentrifuge

Charles B. Reimer 1, Robert S. Baker 1, Thomas E. Newlin 1, and Milton L. Havens 1

1 Eli Lilly Research and Biological Development Laboratories, Indianapolis, Indiania

Sufficient amounts of influenza virus (density, 1.185; size, 722S) can be highly purified (22,000 chicken cell agglutinating units per milligram of protein) with a zonal ultracentrifuge, used first in a rate process followed by isopycnic banding, to permit its detailed biological and physical-chemical evaluation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Invited Commentary: Use of Selective Viral Cultures to Adjust Nonvirologic Endpoints in Studies of Influenza Vaccine Efficacy.
A. S. Monto (2003)
Am. J. Epidemiol. 158, 312-315
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Purified Influenza Virus Vaccine: A Study of Viral Reactivity and Antigenicity.
F. B. Peck Jr. (1968)
JAMA 206, 2277-2282
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Zonal Centrifuges and Other Separation Systems.
N. G. Anderson (1966)
Science 154, 103-112
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