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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1378 - 1379
DOI: 10.1126/science.152.3727.1378
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Articles

Lymphoid Cells Producing Antibody Against Simple Haptens: Detection and Enumeration

Bruce Merchant 1 and Tomas Hraba 1

1 Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Enumeration of cells producing antibody against arsanilic acid was made feasible by the use of hapten-conjugated sheep erythrocytes for the localized hemolysis-in-gel technique. The time of appearance and numbers of these hapten-specific plaque-forming cells correlated closely with the development of arsanilic acid-specific serum antibodies.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Autoradiographic Plaques for the Detection of Antibody Formation to Soluble Proteins by Single Cells.
E. Pick and J. D. Feldman (1967)
Science 156, 964-966
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Science. ISSN 0036-8075 (print), 1095-9203 (online)