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Science 3 June 1966:
Vol. 152. no. 3727, pp. 1374 - 1375
DOI: 10.1126/science.152.3727.1374
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Articles

Chloroquine: Physiological Basis of Drug Resistance in Plasmodium berghei

Peter B. Macomber 1, Richard L. O'Brien 2, and Fred E. Hahn 2

1 Department of Experimental Pathology
2 Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D.C. 20012

Mouse erythrocytes, parasitized by chloroquine-sensitive plasmodia, concentrate this drug in vivo to levels over twice as high as erythrocytes parasitized by chloroquine-resistant plasmodia; nonparasitized red cells accumulate little chloroquine. Selective toxicity of this drug may depend upon a special drug-concentrating mechanism of plasmodic impairment of such mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Reversal of chloroquine resistance in malaria parasite Plasmodium falciparum by desipramine.
A. Bitonti, A Sjoerdsma, P. McCann, D. Kyle, A. Oduola, R. Rossan, W. Milhous, and D. Davidson Jr (1988)
Science 242, 1301-1303
   Abstract »    PDF »
Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.
S. Martin, A. Oduola, and W. Milhous (1987)
Science 235, 899-901
   Abstract »    PDF »
Plasmodium falciparum in Owl Monkeys: Drug Resistance and Chloroquine Binding Capacity.
C. D. Fitch (1970)
Science 169, 289-290
   Abstract »    PDF »


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