Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 May 1966:
Vol. 152. no. 3725, pp. 1080 - 1082
DOI: 10.1126/science.152.3725.1080
Prev | Table of Contents | Next

Articles

Heme Stimulation of Globin Synthesis in a Cell Free System

Claire L. Hammel 1 and Samuel P. Bessman 1

1 Pediatrics Research Laboratory, School of Medicine, University of Maryland, Baltimore

In a cell-free system of pigeon erythrocyte nuclei high concentrations of oxygen inhibit globin synthesis because of the inhibition of heme synthesis, which is required for globin synthesis. The effect of heme in overcoming the inhibition of globin synthesis by oxygen is manifested only during the first few minutes of incubation. This period represents the time during which the system is being warmed from 4° to 37°C. The effect of heme seems to be upon some initial assembly or structural process.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Translational Control in Hemoglobin Synthesis.
M. Rabinovitz, M. L. Freedman, J. M. Fisher, and C. R. Maxwell (1969)
Cold Spring Harb Symp Quant Biol 34, 567-578
   Abstract »    PDF »
Hemin: An Inhibitor of Erythroid Cell Ribonuclease.
E. R. Burka (1968)
Science 162, 1287
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)