Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 20 May 1966:
Vol. 152. no. 3725, pp. 1066 - 1068
DOI: 10.1126/science.152.3725.1066
Prev | Table of Contents | Next

Articles

Multiple Sclerosis: Serum Factor Producing Reversible Alterations in Bioelectric Responses

Jean A. Cerf 1 and Guy Carels 1

1 Laboratory of Neurophysiology, Faculty of Sciences, University of Brussels, and Centre National de Triage et de Réadaptation, Ligue Belge de la Selérose en Plaques, Melsbroek, Belgium

Serums obtained from patients during acute exacerbations of multiple sclerosis produce a reversible depression of polysynaptic reflex responses when applied to the isolated spinal cord of the frog. Motoneuron discharges initiated by monosynaptic activation through an axosomatic spinal pathway are much less affected than reflex discharges. The active factor in serum appears to depend on the presence of complement.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The pentapeptide QYNAD does not block voltage-gated sodium channels.
T.R. Cummins, M. Renganathan, P.K. Stys, R.I. Herzog, K. Scarfo, R. Horn, S.D. Dib-Hajj, and S.G. Waxman (2003)
Neurology 60, 224-229
   Abstract »    Full Text »    PDF »
Effects of Temperature in Multiple Sclerosis: A Review of the Literature.
K. Syndulko, M. Jafari, A. Woldanski, R. W. Baumhefner, and W. W. Tourtellotte (1996)
Neurorehabil Neural Repair 10, 23-34
   Abstract »    PDF »
Studies of Hyperthermia in Optic Neuropathy: Consideration of a Humoral Factor.
P. H. Zweifach (1978)
Arch Ophthalmol 96, 1831-1834
   Abstract »    PDF »
Neuroelectric Blocking Factors in Multiple Sclerosis and Normal Human Sera.
F. J. Seil, A. L. Leiman, and J. M. Kelly III (1976)
Arch Neurol 33, 418-422
   Abstract »    PDF »
Leukocyte Sensitivity to Brain Fractions in Neurological Diseases.
E. C. Alvord Jr., P. C. Hsu, and R. Thron (1974)
Arch Neurol 30, 296-299
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)