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Science 6 May 1966:
Vol. 152. no. 3723, pp. 778 - 780
DOI: 10.1126/science.152.3723.778
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Articles

Retention of Potential to Differentiate in Long-Term Cultures of Tooth Germs

James H. P. Main 1

1 Department of Dental Surgery, University of Edinburgh, Edinburgh 1, Scotland

When tooth germs derived from 14-day mouse embryos were cultured on gelatin sponges in vitro for 37 days, they lost their characteristic morphology, appearing as a layer of undifferentiated epithelium on the sponge surface, with the mesenchymal cells scattered throughout the interstices. These cultures were then transplanted subcutaneously into isologous, newborn recipients and, over a period of 56 days, developed into incisor teeth that were almost perfect in shape and structure.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transformation of Odontogenic Epithelium by Polyoma Virus In Vitro.
J. H.P. Main (1969)
Journal of Dental Research 48, 738-744
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