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Science 22 April 1966:
Vol. 152. no. 3721, pp. 535 - 538
DOI: 10.1126/science.152.3721.535
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Articles

Lymphocytes from Thymectomized Rats: Immunologic, Proliferative, and Metabolic Properties

William O. Rieke 1

1 Department of Biological Structure, University of Washington, Seattle 98105

Thoracic duct lymphocytes from neonatally thymectomized Lewis rats fail to produce runt disease in newborn Brown Norway rats when injected with up to ten times the number of normal lymphocytes needed to cause runting. The immunologically deficient lymphocytes appear, however, to confer tolerance, and at least some enlarge and divide when stimulated in vitro with phytohemagglutinin, or xenogeneic or allogeneic cells. Small lymphocytes from thymectomized animals have defective RNA metabolism as judged by a marked impairment in their ability to incorporate uridine-5-H3 or cytidine-H3 in vitro.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bone Marrow and Spleen: Dissociation of Immunologic Properties by Cortisone.
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Immunologic Memory of the Normal and the Leukemic Lymphocyte.
J. I. BRODY and F. OSKI (1967)
Ann Intern Med 67, 573-578
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