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Science 22 April 1966:
Vol. 152. no. 3721, pp. 525 - 526
DOI: 10.1126/science.152.3721.525
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Articles

Nicotinamide-Adenine Dinucleotide in Tubercle Bacilli Exposed to Isoniazid

A. Bekierkunst 1

1 Department of Bacteriology, Hebrew University, Hadassah Medical School, Jerusalem, Israel

There is a decrease in the content of nicotinamide-adenine dinucleotide of tubercle bacilli grown in the presence of isoniazid. In extracts of tubercle bacilli, the activity of nicotinamide-adenine dinucleotidase is nil or very small; after incubation with the drug the enzyme becomes active. Isoniazid also increases the activity of the enzyme after it is partially activated by heating. There may be a correlation between the capacity of isoniazid to activate the enzyme and the decrease in the dinucleotide content of the tubercle bacilli.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis.
P. C. Karakousis, E. P. Williams, and W. R. Bishai (2008)
J. Antimicrob. Chemother. 61, 323-331
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R. Cantoni, M. Branzoni, M. Labò, M. Rizzi, and G. Riccardi (1998)
J. Bacteriol. 180, 3218-3221
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