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Science 8 April 1966:
Vol. 152. no. 3719, pp. 205 - 207
DOI: 10.1126/science.152.3719.205
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Articles

Iodoinsulin Used To Determine Specific Activity of Iodine-131

Solomon A. Berson 1 and Rosalyn S. Yalow 1

1 Radioisotope Service, Veterans Administration Hospital, Bronx, New York

Anodal mobility of iodoinsulin on starch-gel electrophoresis increases progressively as the number of iodine atoms substituted in the molecule increases. The iodine content of iodine-131 solutions is determined by comparison of autoradiographic patterns of insulin heavily labeled with iodine-131 and of insulins lightly labeled with iodine-131 and known quantities of iodine-127.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)