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Science 1 April 1966:
Vol. 152. no. 3718, pp. 83 - 85
DOI: 10.1126/science.152.3718.83
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Articles

Liver Carcinogenesis by Diethylnitrosamine in the Rat

M. F. Rajewsky 1, W. Dauber 1, and H. Frankenberg 1

1 Max-Planck-Institut für Biophysik, 6 Frankfurt am Main, Kennedy Allee 70, Germany

Diethylnitrosamine was continuously administered to rats at a dose rate of low toxicity. Ninety-two percent of the animals died with multicentrical hepatocellular carcinomata within a narrow and highly reproducible time interval. Discontinuing the carcinogen during the experiment resulted in a prolonged median time until death, a reduced tumor yield, and a lessened slope of the dose-response curve. Partial hepatectomy after discontinuation of the drug did not change either tumor yield or time of death. The obtained dose-response relationships support the concept that carcinogenic effects of single doses are irreversible and cumulative. Daily, low-dose, total-body x-irradiation had no significant effect on the response of rat liver to the carcinogen.


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Ultrastructure of altered hepatocytes induced by diethylnitrosamine (DENA).
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DENA altered hepatic cells.
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