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Science 1 April 1966:
Vol. 152. no. 3718, pp. 78 - 80
DOI: 10.1126/science.152.3718.78
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Articles

Increased Incidence of Lymphoma after Injections of Mice with Cells Differing at Weak Histocompatibility Loci

Roy L. Walford 1

1 Department of Pathology, University of California School of Medicine, Los Angeles

Newborns of two congenic strains of mice, in which the incidence of leukemia is low, differing only at the weak H-1 locus, were. injected at birth with adult spleen cells of the parent and of the congenic strain. A marked increase in the incidence of lymphoma ensued in those mice of both strains injected with cells from the other strain. The experiment lends some support to the idea that transplantation immunologic mechanisms may play a role in the genesis of lymphomas.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Pseudolymphoma in Renal Allograft Recipients.
W. P. Geis, S. Iwatsuki, Z. Molnar, J. L. Giacchino, R. H. Kerman, T. S. Ing, and J. E. Hano (1978)
Arch Surg 113, 461-466
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Maternally Acquired Runt Disease: Immune lymphocytes from the maternal blood can traverse the placenta and cause runt disease in the progeny.
A. E. Beer and R. E. Billingham (1973)
Science 179, 240-243
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Lymphomas in Mice: Failure of Induction after a Graft-versus-Host Reaction.
G. B. Rossi and C. Friend (1970)
Science 167, 1383-1385
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Cerebral Neoplasms Associated With Renal Transplantation.
S. A. Schneck and I. Penn (1970)
Arch Neurol 22, 226-233
   Abstract »    PDF »
The Role of Immunologic Aberrations in the Pathogenesis of Lymphoma: With Particular Reference to Mycosis Fungoides and Exfoliative Erythroderma.
S. M. Bierman (1968)
Arch Dermatol 97, 699-711
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