Actin-Myosin Interaction: Inhibition of the Myosin Adenosine Triphosphatase by Actin
S. Barron 1,
E. Eisenberg 1, and
C. Moos 1
1 Department of Biophysics, State University of New York at Buffalo
In the absence of magnesium ion, the addition of actin to myosin in a 1 :4 ratio has a strong inhibitory effect on the adenosine triphosphatase activity, in contrast to the well-known activating effect of actin in the presence of magnesium ion. This finding suggests that both effects result from a conformational change in the active site of the myosin adenosine triphosphatase.