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Science 25 March 1966:
Vol. 151. no. 3717, pp. 1541 - 1542
DOI: 10.1126/science.151.3717.1541

Articles

Actin-Myosin Interaction: Inhibition of the Myosin Adenosine Triphosphatase by Actin

S. Barron 1, E. Eisenberg 1, and C. Moos 1

1 Department of Biophysics, State University of New York at Buffalo

In the absence of magnesium ion, the addition of actin to myosin in a 1 :4 ratio has a strong inhibitory effect on the adenosine triphosphatase activity, in contrast to the well-known activating effect of actin in the presence of magnesium ion. This finding suggests that both effects result from a conformational change in the active site of the myosin adenosine triphosphatase.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)