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Science 25 February 1966:
Vol. 151. no. 3713, pp. 998 - 999
DOI: 10.1126/science.151.3713.998
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Articles

Antagonism of Purified Asparaginase from Guinea Pig Serum toward Lymphoma

Tobias O. Yellin 1 and John C. Wriston Jr. 1

1 Department of Chemistry, University of Delaware, Newark

The tumor inhibitory activity of highly purified asparaginase from guinea pig serum toward the Gardner lymphosarcoma in C3H mice was compared with that of the serum itself. The purified enzyme, homogeneous by ultracentrifugation and immunoelectrophoresis, had activity comparable to that of the serum. The serum was also effective in mice which were made immunologically incompetent by radiation with coba't-60.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Asparagine Synthetase Activity of Mouse Leukemias.
B. Horowitz, B. K. Madras, A. Meister, L. J. Old, E. A. Boyse, and E. Stockert (1968)
Science 160, 533-535
   Abstract »    PDF »
L-Asparaginase Therapy for Leukemia and Other Malignant Neoplasms: Remission in Human Leukemia.
J. M. Hill, J. Roberts, E. Loeb, A. Khan, A. MacLellan, and R. W. Hill (1967)
JAMA 202, 882-888
   Abstract »    PDF »


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