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Science 11 February 1966:
Vol. 151. no. 3711, pp. 696 - 698
DOI: 10.1126/science.151.3711.696
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Articles

Morphogenesis in Trichoderma: Suppression of Photoinduction by 5-Fluorouracil

Esra Galun 1 and Jonathan Gressel 1

1 Section of Planit Genetics, Weizmann Institute of Science, Rehovoth, Israel

Sporulation in the fungus Trichoderma viride is inducible with a short light pulse. 5-Fluorouracil applied prior to photoinduction and removed thereafter suppressed sporulation without greatly aflecting growth. This compound also halved the rate of incorporation of uracil-C14 into RNA but did not change the ratio of uridylic to cytidylic acid. The effect of 5-fluorouracil was counteracted by uracil but not by thymidine. This supports the hypothesis that 5-fluorouracil affects RNA rather than DNA.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)