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Science 21 January 1966:
Vol. 151. no. 3708, pp. 332 - 333
DOI: 10.1126/science.151.3708.332
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Articles

Tryptophan Pyrrolase Induced in Human Liver by Hydrocortisone: Effect on Excretion of Kynurenine

Kurt Altman 1 and Olga Greengard 1

1 Department of Internal Medicine, New York Medical College, and Institute for Muscle Disease, New York

Administration of hydrocortisone causes two- to fourfold increase in the level of activity of tryptophan pyrrolase in human liver, as measured in needle-biopsy specimens. Correlation of the higher levels of the enzyme with the amounts of urinary kynurenine suggests that the tryptophan pyrrolase level, which is regulated by adrenocortical hormones, may be the important variable in the increased excretion of tryptophan metabolites that accompanies various diseases.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Adrenal Cortical Activity Changes in Manic-Depressive Illness: Influence on Intermediary Metabolism of Tryptophan.
R. T. Rubin (1967)
Arch Gen Psychiatry 17, 671-679
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Science. ISSN 0036-8075 (print), 1095-9203 (online)