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Science 14 January 1966:
Vol. 151. no. 3707, pp. 221 - 223
DOI: 10.1126/science.151.3707.221
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Articles

Anticholinesterase-Induced Amnesia and Its Temporal Aspects

J. A. Deutsch 1, M. D. Hamburg 1, and H. Dahl 2

1 Department of Psychology, New York University, New York
2 Research Center for Mental Health, New York University

Injection of the anticholinesterase drug diisopropyl fluorophosphate into the hippocampi of rats, 30 minutes after escape learning, produces partial amnesia with full recovery 5 days after injection. No such amnesia is produced if the injection takes place 3 days after learning. However, with injections 5 days after learning there is again an effect, and at 14 days amnesia is complete though no normal forgetting occurs within this period.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Cholinergic Synapse and the Site of Memory.
J. A. Deutsch (1971)
Science 174, 788-794
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Memory Impairment after Subcutaneous Injection of Acetoxycycloheximide.
S. H. Barondes and H. D. Cohen (1968)
Science 160, 556-557
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Retrograde Amnesia Produced by Intraperitoneal Injection of Physostigmine.
M. D. Hamburg (1967)
Science 156, 973-974
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Time-Dependent Processes in Memory Storage.
J. L. McGaugh (1966)
Science 153, 1351-1358
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Amnesia or Reversal of Forgetting by Anticholinesterase, Depending Simply on Time of Injection.
J. A. Deutsch and S. F. Leibowitz (1966)
Science 153, 1017-1018
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