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Science 14 January 1966:
Vol. 151. no. 3707, pp. 209 - 210
DOI: 10.1126/science.151.3707.209
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Articles
Sorbitol Pathway: Presence in Nerve and Cord with Substrate Accumulation in Diabetes
Kenneth H. Gabbay 1,
Lorenzo O. Merola 1, and
Richard A. Field 1
1 Department of Medicine (Diabetes Unit), Massachusetts General Hospital, and Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston
Glucose, sorbitol, fructose, and inositol are present in peripheral nerve and spinal cord. Marked elevation of these substances occurs in these tissues in mildly diabetic animals. These alterations provide biochemical mechanisms which could be significant in the etiology of diabetic neuropathy.
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