Spleen as a Production Site for Erythropoietin
Pietro de Franciscis 1,
Gregorio De Bella 1, and
Secondo Cifaldi 1
1 Department of Human Physiology, Medical School, University of Naples, Naples, Italy
Mice treated with acellular extracts of spleen and liver show a pronounced and significant increase in blood reticulocytes. In control mice treated with saline and extracts of kidney, muscle, and liver of splenectomizedmice and rats, the number of reticulocytes remained constant in all the cases.