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Science 31 December 1965:
Vol. 150. no. 3705, pp. 1831 - 1833
DOI: 10.1126/science.150.3705.1831

Articles

Spleen as a Production Site for Erythropoietin

Pietro de Franciscis 1, Gregorio De Bella 1, and Secondo Cifaldi 1

1 Department of Human Physiology, Medical School, University of Naples, Naples, Italy

Mice treated with acellular extracts of spleen and liver show a pronounced and significant increase in blood reticulocytes. In control mice treated with saline and extracts of kidney, muscle, and liver of splenectomizedmice and rats, the number of reticulocytes remained constant in all the cases.





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Science. ISSN 0036-8075 (print), 1095-9203 (online)