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Science 17 December 1965:
Vol. 150. no. 3703, pp. 1613 - 1614
DOI: 10.1126/science.150.3703.1613
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Articles

Myelin Membrane: A Molecular Abnormality

John S. O'Brien 1 and E. Lois Sampson 1

1 Division of Chemical Pathology, Departments of Pathology and Medicine, University of Southern California School of Medicine, Los Angeles

Myelin was isolated from cerebral white matter from a patient who had died of metachromatic leukodystrophy, and its lipid composition was analyzed. Although the lipid content was nearly normal, the myelin contained a three- to fourfold excess of cerebroside sulfate and a threefold deficiency of cerebroside compared to normal myelin. The deficiency of cerebroside and the excess of cerebroside sulfate may account for defective myelination in this disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Sulfatides and Demyelination: Subcellular Localization in Metachromatic Leukodystrophy.
M. J. Malone and J. Conole (1969)
Arch Neurol 21, 32-43
   Abstract »    PDF »
Infantile Niemann-Pick Disease: A Chemical Study With Isolation and Characterization of Membranous Cytoplasmic Bodies and Myelin.
S. Kamoshita, A. M. Aron, K. Suzuki, and K. Suzuki (1969)
Arch Pediatr Adolesc Med 117, 379-394
   Abstract »    PDF »
Lipid Metabolism in Cerebral Edema Associated With Human Brain Tumor.
T. Yanagihara and J. N. Cumings (1968)
Arch Neurol 19, 241-247
   Abstract »    PDF »
Metachromatic Leukodystrophy (MLD) VIII. MLD in Adults; Diagnosis and Pathogenesis.
J. Austin, D. Armstrong, S. Fouch, C. Mitchell, D. Stumpf, L. Shearer, and O. Briner (1968)
Arch Neurol 18, 225-240
   Abstract »    PDF »


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