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Science 17 December 1965:
Vol. 150. no. 3703, pp. 1611 - 1613
DOI: 10.1126/science.150.3703.1611
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Articles

Steroid Stimulation of Beating of Cultured Rat-Heart Cells

Richard L. McCari 1, Bernard F. Szuhaj 1, and Rodney T. Houlihan 2

1 Department of Biochemistry, Pennsylvania State University, University Park
2 Department of Zoology

The addition of cortisol acetate and deoxycorticosterone acetate to cultured heart cells from rats, 4 to 6 days old, stimulated and prolonged beating. Protein synthesis was slowed down in the presence of steroids. Addition of steroids to cells that had stopped beating caused the reestablishiment of the beat.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)