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Science 26 November 1965:
Vol. 150. no. 3700, pp. 1175 - 1177
DOI: 10.1126/science.150.3700.1175
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Articles

Immunoglobulin A Production in Ataxia Telangiectasia

D. E. McFarlin 1, W. Strober 2, R. D. Wochner 2, and T. A. Waldmann 2

1 National Institute of Neurological Diseases and Blindness, Bethesda, Maryland
2 National Cancer Institute, Bethesda, Maryland

Serum from five patients with ataxia telangiectasia contained no detectable immunoglobulin A (IgA). However, there was evidence (by immunofluorescence) of IgA in the bone marrow of the three patients so examined, suggesting that the defect in IgA production was not complete. IgA was in the saliva of all five patients and in the parotid gland of the one patient studied. This is further evidence of IgAsynthesis by the salivary glands.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Immunoglobulin M: Local Synthesis and Selective Secretion in Patients with Immunoglobulin A Deficiency.
P. Brandtzaeg, I. Fjellanger, and S. T. Gjeruldsen (1968)
Science 160, 789-791
   Abstract »    PDF »
Selected Reviews of the Literature.
W. G. LARSEN (1966)
Arch Dermatol 94, 226-227
   PDF »
Antiserum to Immunoglobulin A: Inhibition of Cell-Mediated Demyelination in Tissue Culture.
G. F. Winkler and B. G. Arnason (1966)
Science 153, 75-76
   Abstract »    PDF »


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