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Science 19 November 1965:
Vol. 150. no. 3699, pp. 1044 - 1046
DOI: 10.1126/science.150.3699.1044
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Articles

Oncogenicity of the Simian Adenoviruses

Robert N. Hull 1, Irving S. Johnson 1, Clyde G. Culbertson 1, Charles B. Reimer 1, and Howard F. Wright 1

1 Lilly Research Laboratories, Indianapolis, Indiana

Five of 17 adenoviruses of rhesus or cynomolgus monkey origin induced tumors in newborn hamsters. The tumors appeared between 42 and 280 days after subcutaneous inoculation and had the general characteristics of lymphomas. The tumors were specific by cross-complement fixation tests. An adenovirus recovered from Cercopithecus monkeys appeared to be highly oncogenic; all 23 inoculated hamsters developed tumors within 30 to 40 days.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Complete genome sequence of simian adenovirus 1: an Old World monkey adenovirus with two fiber genes.
G. M. Kovacs, B. Harrach, A. N. Zakhartchouk, and A. J. Davison (2005)
J. Gen. Virol. 86, 1681-1686
   Abstract »    Full Text »    PDF »
Analysis of the first complete genome sequence of an Old World monkey adenovirus reveals a lineage distinct from the six human adenovirus species.
G. M. Kovacs, A. J. Davison, A. N. Zakhartchouk, and B. Harrach (2004)
J. Gen. Virol. 85, 2799-2807
   Abstract »    Full Text »    PDF »
Transforming Activity of Green Monkey SA7 (C8) Adenovirus in Tissue Culture.
A. D. Altstein, O. F. Sarycheva, and N. N. Dodonova (1967)
Science 158, 1455-1457
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