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Science 12 November 1965:
Vol. 150. no. 3698, pp. 901 - 903
DOI: 10.1126/science.150.3698.901
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Articles

Effect of Gamma Radiation on Dietary and Hormonal Induction of Enzymes in Rat Liver

Henry C. Pitot 1, Carl Peraino 1, Carlos Lamar Jr. 1, and Sam Lesher 2

1 McArdle Laboratory, the Medical School, University of Wisconsin, Madison
2 Argonne National Laboratory, Argonne, Illinois

The dietary induction of serine dehydrase, produced by the oral intubation of hydrolyzed casein to protein-depleted rats, is markedly inhibited by doses of ggr-radiation of 400 roentgens or higher provided the irradiation is given within an hour after the initial dose of casein. If the irradiation is delayed until 7 hours after the initial dose of casein, induction is not inhibited. In contrast, the cortisone induction of tyrosine agr-ketoglutarate transaminase is not inhibited by doses of ggr-radiation up to 3200 roentgens; in some instances hormonal induction of this enzyme appears to be enhanced by irradiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition of Lipolytic Action of Growth Hormone and Glucocorticoid by Ultraviolet and X-Radiation.
J. N. Fain (1967)
Science 157, 1062-1064
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Science. ISSN 0036-8075 (print), 1095-9203 (online)