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Science 12 November 1965:
Vol. 150. no. 3698, pp. 893 - 899
DOI: 10.1126/science.150.3698.893
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Articles

Bone: Formation by Autoinduction

Marshall R. Urist 1

1 Department of Surgery, University of California Center for Health Sciences, Los Angeles 90024

Wandering histiocytes, foreign body giant cells, and inflammatory connective-tissue cells are stimulated by degradation products of dead matrix to grow in and repopulate the area of an implant of decalcified bone. Histiocytes are more numerous than any other cell form and may transfer collagenolytic activity to the substrate to cause dissolution of the matrix. The process is followed immediately by new-bone formation by autoinduction in which both the inductor cells and the induced cells are derived from ingrowing cells of the host bed. The inductor cell is a descendant of a wandering histiocyte; the induced cell is a fixed histiocyte or perivascular young connective-tissue cell. Differentiation of the osteoprogenitor cell is elicited by local alterations in cell metabolic cycles that are as yet uncharacterized.


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Journal of Dental Research 84, 390-406
   Abstract »    Full Text »    PDF »
Low Turnover Osteodystrophy and Vascular Calcification Are Amenable to Skeletal Anabolism in an Animal Model of Chronic Kidney Disease and the Metabolic Syndrome.
M. R. Davies, Richard. J. Lund, S. Mathew, and K. A. Hruska (2005)
J. Am. Soc. Nephrol. 16, 917-928
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Use of Bone Morphogenetic Proteins for Musculoskeletal Applications: An Overview.
M. A. Mont, P. S. Ragland, B. Biggins, G. Friedlaender, T. Patel, S. Cook, G. Etienne, A. Shimmin, R. Kildey, D. C. Rueger, et al. (2004)
J. Bone Joint Surg. Am. 86, 41-55
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Deletion of Epidermal Growth Factor-like Domains Converts Mammalian Tolloid into a Chordinase and Effective Procollagen C-proteinase.
L. Garrigue-Antar, V. Francois, and K. E. Kadler (2004)
J. Biol. Chem. 279, 49835-49841
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Conservation of Bmp2 Post-transcriptional Regulatory Mechanisms.
D. T. Fritz, D. Liu, J. Xu, S. Jiang, and M. B. Rogers (2004)
J. Biol. Chem. 279, 48950-48958
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Bone Morphogenetic Protein (BMP)-6 Signaling and BMP Antagonist Noggin in Prostate Cancer.
D. R. Haudenschild, S. M. Palmer, T. A. Moseley, Z. You, and A. H. Reddi (2004)
Cancer Res. 64, 8276-8284
   Abstract »    Full Text »    PDF »
What's New in Orthopaedic Rehabilitation.
N. Hebela, D. G. Smith, and M. A. Keenan (2004)
J. Bone Joint Surg. Am. 86, 2577-2581
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FGF18 Represses Noggin Expression and Is Induced by Calcineurin.
M. I. Reinhold, M. Abe, R. M. Kapadia, Z. Liao, and M. C. Naski (2004)
J. Biol. Chem. 279, 38209-38219
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Molecular, Endocrine, and Genetic Mechanisms of Arterial Calcification.
T. M. Doherty, L. A. Fitzpatrick, D. Inoue, J.-H. Qiao, M. C. Fishbein, R. C. Detrano, P. K. Shah, and T. B. Rajavashisth (2004)
Endocr. Rev. 25, 629-672
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Growth Differentiation Factor 9 Regulates Expression of the Bone Morphogenetic Protein Antagonist Gremlin.
S. A. Pangas, C. J. Jorgez, and M. M. Matzuk (2004)
J. Biol. Chem. 279, 32281-32286
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Bone Morphogenetic Protein Type IA Receptor Signaling Regulates Postnatal Osteoblast Function and Bone Remodeling.
Y. Mishina, M. W. Starbuck, M. A. Gentile, T. Fukuda, V. Kasparcova, J. G. Seedor, M. C. Hanks, M. Amling, G. J. Pinero, S.-i. Harada, et al. (2004)
J. Biol. Chem. 279, 27560-27566
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Protein Related to DAN and Cerberus Is a Bone Morphogenetic Protein Antagonist That Participates in Ovarian Paracrine Regulation.
S. Sudo, O. Avsian-Kretchmer, L. S. Wang, and A. J. W. Hsueh (2004)
J. Biol. Chem. 279, 23134-23141
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An Evolutionary and Molecular Analysis of Bmp2 Expression.
K. L. Abrams, J. Xu, C. Nativelle-Serpentini, S. Dabirshahsahebi, and M. B. Rogers (2004)
J. Biol. Chem. 279, 15916-15928
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MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures.
M. Komaki, A. Asakura, M. A. Rudnicki, J. Sodek, and S. Cheifetz (2004)
J. Cell Sci. 117, 1457-1468
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BIG-3, a Novel WD-40 Repeat Protein, Is Expressed in the Developing Growth Plate and Accelerates Chondrocyte Differentiation in Vitro.
F. Gori and M. B. Demay (2004)
Endocrinology 145, 1050-1054
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The Bone Morphogenetic Protein System In Mammalian Reproduction.
S. Shimasaki, R. K. Moore, F. Otsuka, and G. F. Erickson (2004)
Endocr. Rev. 25, 72-101
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