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Science 29 October 1965:
Vol. 150. no. 3696, pp. 616 - 617
DOI: 10.1126/science.150.3696.616
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Articles

Glycerol Metabolism in the Human Liver: Inhibition by Ethanol

Frank Lundquist 1, Niels Tygstrup 1, Kjeld Winkler 1, and K. Birger Jensen 1

1 Department of Biochemistry A, University of Copenhagen, and Departments of Medicine B and Clinical Physiology, Bispebjerg Hospital, Copenhagen, Denmark

Glycerol is metabolized predominantly in the liver, the first step presumably being phosphorylation to agr-glycerophosphate. When ethanol is present in the blood the rate of glycerol uptake by the splanchnic organs is reduced to about one-third of the control value. At the same time glycerophosphate accumulates in the liver. Hepatic blood flow and oxygen consumption are not influenced by the combined infusion of glycerol and ethanol. The phenomenon may be connected with the increased concentration of the reduced form of diphosphopyridine nucleotide present in the liver during ethanol metabolism.


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