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Science 15 October 1965:
Vol. 150. no. 3694, pp. 363 - 364
DOI: 10.1126/science.150.3694.363
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Articles

Lymphocytic-Choriomeningitis Virus in Hamster Tumor: Spread to Hamsters and Humans

Andrew M. Lewis Jr. 1, Wallace P. Rowe 1, Horace C. Turner 1, and Robert J. Huebner 1

1 National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

A passage line of a spontaneous hamster fibrosarcoma is contaminated by the virus. of lymphocytic choriomeningitis. Tumors from animals receiving implants when newborn contain high titers of infectious lymphocytic-choriomeningitis virus and complement-fixing antigen, and hamsters receiving implants when weanlings develop high titers of complement-fixing antibody against lymphocytic-choriomeningitis virus. In contrast with the specific reactions of tumorous hamsters to the initiating virus in virus-induced tumors, the development of complement-fixing antibody to lymphocytic-choriomeningitis virus does not depend on the development of tumors. Infant hamsters bearing the tumor have a generalized subclinical infection and seem able to spread virus to other hamsters and to humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Lymphocytic Choriomeningitis Outbreak Associated With Nude Mice in a Research Institute.
C. A. Dykewicz, V. M. Dato, S. P. Fisher-Hoch, M. V. Howarth, G. I. Perez-Oronoz, S. M. Ostroff, H. Gary Jr, L. B. Schonberger, and J. B. McCormick (1992)
JAMA 267, 1349-1353
   Abstract »    PDF »
Lymphocytic Choriomeningitis Outbreak Associated With Pet Hamsters: Fifty-Seven Cases From New York State.
R. J. Biggar, J. P. Woodall, P. D. Walter, and G. E. Haughie (1975)
JAMA 232, 494-500
   Abstract »    PDF »
Lymphocytic Choriomeningitis in a Hamster Colony Causes Infection of Hospital Personnel.
J. Hotchin, E. Sikora, W. Kinch, A. Hinman, and J. Woodall (1974)
Science 185, 1173-1174
   Abstract »    PDF »
Meningitis Due to Lymphocytic Choriomeningitis Virus Endemic in a Hamster Colony.
D. Armstrong, J. G. Fortner, W. P. Rowe, and J. C. Parker (1969)
JAMA 209, 265-267
   Abstract »    PDF »


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