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Science 8 October 1965:
Vol. 150. no. 3693, pp. 212 - 214
DOI: 10.1126/science.150.3693.212
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Articles

Anomalous Dispersion Method: Its Power for Protein Structure Analysis

G. N. Ramachandran 1 and S. Parthasarathy 1

1 Center of Advanced Study in Physics, University of Madras, Madras 25, India

The phases of x-ray reflection of a crystal can be measured, except for an ambiguity, if the crystal contains heavy atoms which scatter x-rays anomalously. Theoretical studies show that the method of resolving this ambiguity by choosing the phases closer to those of the heavy atoms has a good potentiality for solving complicated structures, in which the average heavy atom contribution to the intensity is as low as 10 percent.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)