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Science 10 September 1965:
Vol. 149. no. 3689, pp. 1251 - 1254
DOI: 10.1126/science.149.3689.1251
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Articles

Actinomycin D and Hydrocortisone: Intracellular Binding in Rat Liver

C. W. Dingman 1 and M. B. Sporn 1

1 National Cancer Institute, Bethesda, Maryland 20014

DNA was found to be the major intracellular binding site for labeled actinomycin D administered in vivo. In analogous studies, hydrocortisone did not bind to nuclear structures. Furthermore, following the administration of actinomycin D, a highly positive correlation was found between the RNA content of the nucleus and the ability of the nucleus to synthesize RNA.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Aflatoxin B1: Binding to DNA in vitro and Alteration of RNA Metabolism in vivo.
M. B. Sporn, C. W. Dingman, H. L. Phelps, and G. N. Wogan (1966)
Science 151, 1539-1541
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