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Science 3 September 1965:
Vol. 149. no. 3688, p. 1108
DOI: 10.1126/science.149.3688.1108
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Articles

Induction of Tumors in Hamsters with an Avian Adenovirus (CELO)

Padman S. Sarma 1, Robert J. Huebner 2, and William T. Lane 2

1 Microbiological Associates, Inc., Bethesda, Maryland
2 Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland

When newborn hamsters were inoculated subcutaneously with chicken-embryo lethal orphan virus, tumnors developed at the site of inoculation in 23 out of 69 hamsters within 88 to 195 days of inoculation. These tutlnors and tissue cultures, prepared from a primary tumor, were transplantable to newborn and weanling hamsters. The primary tumnors and tissue cultures of a primary tumor were free of demnonstrable infectious virus. The virus is the first "nonhuman" adenovirus found to induce tumors in hamsters.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Characterization of CELO Virus Proteins That Modulate the pRb/E2F Pathway.
H. Lehrmann and M. Cotten (1999)
J. Virol. 73, 6517-6525
   Abstract »    Full Text »    PDF »
Transcriptional Organization of the Avian Adenovirus CELO.
V. Payet, C. Arnauld, J.-P. Picault, A. Jestin, and P. Langlois (1998)
J. Virol. 72, 9278-9285
   Abstract »    Full Text »    PDF »
Complement-Fixing Antigens in Hamster Tumors Induced by the Bryan Strain of Rous Sarcoma Virus.
M. J. Casey, G. F. Rabotti, P. S. Sarma, W. T. Lane, H. C. Turner, and R. J. Huebner (1966)
Science 151, 1086-1088
   Abstract »    PDF »
Lymphocytic-Choriomeningitis Virus in Hamster Tumor: Spread to Hamsters and Humans.
A. M. Lewis Jr., W. P. Rowe, H. C. Turner, and R. J. Huebner (1965)
Science 150, 363-364
   Abstract »    PDF »


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