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Science 3 September 1965:
Vol. 149. no. 3688, pp. 1096 - 1098
DOI: 10.1126/science.149.3688.1096
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Articles

Inhibition of Protein Synthesis by Spectinomycin

Julian Davies 1, Porter Anderson 1, and Bernard D. Davis 1

1 Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts

Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. Mutations to high-level resistance to this antibiotic map close to the streptomycin locus, and the site of action of spectinomycin, like that of streptomycin, is the 30S ribosomal subunit, as shown by experiments with reconstituted 70S ribosomes containing subunits from sensitive and from resistant ribosomes. In contrast to streptomycin, however, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Metabolic Defects Caused by Mutations in the isc Gene Cluster in Salmonella enterica Serovar Typhimurium: Implications for Thiamine Synthesis.
E. Skovran and D. M. Downs (2000)
J. Bacteriol. 182, 3896-3903
   Abstract »    Full Text »
Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map.
M. K. B. Berlyn (1998)
Microbiol. Mol. Biol. Rev. 62, 814-984
   Abstract »    Full Text »    PDF »
Escherichia coli: High Resistance or Dependence on Streptomycin Produced by the Same Allele.
L. Luzzatto, D. Schlessinger, and D. Apirion (1968)
Science 161, 478-479
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)