Related Content
Search Google Scholar for:
|
|
Science 3 September 1965: Vol. 149. no. 3688, pp. 1096 - 1098 DOI: 10.1126/science.149.3688.1096
|
|
Articles
Inhibition of Protein Synthesis by Spectinomycin
Julian Davies 1,
Porter Anderson 1, and
Bernard D. Davis 1
1 Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts
Spectinomycin selectively inhibits protein synthesis in cells and in extracts of Escherichia coli. Mutations to high-level resistance to this antibiotic map close to the streptomycin locus, and the site of action of spectinomycin, like that of streptomycin, is the 30S ribosomal subunit, as shown by experiments with reconstituted 70S ribosomes containing subunits from sensitive and from resistant ribosomes. In contrast to streptomycin, however, spectinomycin is not bactericidal and causes no detectable misreading of polyribonucleotides.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Metabolic Defects Caused by Mutations in the isc Gene Cluster in Salmonella enterica Serovar Typhimurium: Implications for Thiamine Synthesis.
- E. Skovran and D. M. Downs (2000)
J. Bacteriol.
182, 3896-3903
| Abstract »
| Full Text »
| PDF »
- Linkage Map of Escherichia coli K-12, Edition 10: The Traditional Map.
- M. K. B. Berlyn (1998)
Microbiol. Mol. Biol. Rev.
62, 814-984
| Abstract »
| Full Text »
| PDF »
- Spectinomycin-Resistant Neisseria gonorrhoeae.
- C. Thornsberry, H. Jaffee, S. T. Brown, T. Edwards, J. W. Biddle, and S. E. Thompson (1977)
JAMA
237, 2405-2406
| Abstract »
| PDF »
- Drugs Five Years Later: Spectinomycin.
- W. M. McCORMACK and M. FINLAND (1976)
Ann Intern Med
84, 712-716
| Abstract »
| PDF »
- The Chemical and Genetic Structure of Bacterial Ribosomes.
- P. S. Sypherd, D. M. O'Neil, and M. M. Taylor (1969)
Cold Spring Harb Symp Quant Biol
34, 77-84
| Abstract »
| PDF »
- Altered Ribosomes in Antibiotic-Resistant Mutants of E. coli.
- A. Bollen, T. Helser, T. Yamada, and J. Davies (1969)
Cold Spring Harb Symp Quant Biol
34, 95-100
| Abstract »
| PDF »
- Approaches to the Genetics of Escherichia coli Ribosomes.
- D. Apirion, S. L. Phillips, and D. Schlessinger (1969)
Cold Spring Harb Symp Quant Biol
34, 117-128
| Abstract »
| PDF »
- Escherichia coli: High Resistance or Dependence on Streptomycin Produced by the Same Allele.
- L. Luzzatto, D. Schlessinger, and D. Apirion (1968)
Science
161, 478-479
| Abstract »
| PDF »
- Mutations and Genetics Concerned With the Ribosome.
- J. G. Flaks, P. S. Leboy, E. A. Birge, and C. G. Kurland (1966)
Cold Spring Harb Symp Quant Biol
31, 623-631
| Abstract »
| PDF »
- Single-Stranded DNA as a Template for in Vitro Protein Synthesis.
- B. J. McCarthy, J. J. Holland, and C. A. Buck (1966)
Cold Spring Harb Symp Quant Biol
31, 683-691
| Abstract »
| PDF »
|
|