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Science 27 August 1965:
Vol. 149. no. 3687, pp. 982 - 983
DOI: 10.1126/science.149.3687.982
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Articles

Double Mating: Its Use To Study Heritable Factors in Dental Caries

Rachel H. Larson 1 and Mildred E. Simms 1

1 National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014

When Osborne-Mendel female rats (white) were mated with both an Osborne-Mendel and an NIH Black rat male during the same breeding period, litters were born which contained both Osborne-Mendel (white) and crossbred (grey to black) offspring. The Osborne-Mendel and crossbred animals developed widely different levels of caries activity even though they were exposed to identical environmental conditions during the intrauterine, preweaning, and experimental periods. These findings are indicative of a strong heritable influence on the development of dental caries.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Patterns of Dental Caries in Osborne-Mendel and NIH Black Rats in Relation to Length of the Caries Test Period.
R. H. Larson and C. S. Zickus (1972)
Journal of Dental Research 51, 1375-1381
   Abstract »    PDF »
Effect of Passive Immunization on the Dental Caries Incidence of Caries-Susceptible Rats.
E.A. Sweeney, J.H. Shaw, and E.L. Childs (1966)
Journal of Dental Research 45, 993-997
   PDF »


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