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Science 20 August 1965:
Vol. 149. no. 3686, pp. 870 - 872
DOI: 10.1126/science.149.3686.870
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Articles

Tetracycline: Effect on Osteogenesis in vitro

Lauri Sax[unknown]n 1

1 Department of Physiological Zoology, University of Helsinki, Helsinki, Finland

Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, mineralization proceeds normally but maldeveloped bones result.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of Tetracyclines on Membranous Bone Growth and Dentin Apposition in Young Rhesus Monkeys.
P. K.-J. Yen and J. H. Shaw (1974)
Journal of Dental Research 53, 897-906
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Science. ISSN 0036-8075 (print), 1095-9203 (online)