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Science 20 August 1965:
Vol. 149. no. 3686, pp. 862 - 863
DOI: 10.1126/science.149.3686.862
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Articles

Cleft Palate Produced in Mice by Human-Equivalent Dosage with Triamcinolone

Bruce E. Walker 1

1 Department of Anatomy, University of Texas Medical Center, Galveston

Triamcinolone produced cleft palates in mouse embryos at a dosage proportionate, by body weight, to common therapeutic dosage for humans. Thus, it showed much greater teratogenicity than other glucocorticoids tested on mice. Widely ranging doses of desoxycorticosterone did not produce cleft palates.


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Effects of Anti-Inflammatory Steroids on Mouse Embryonic Movements During Palatal Development.
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Journal of Dental Research 54, 1200-1206
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Science. ISSN 0036-8075 (print), 1095-9203 (online)