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Science 13 August 1965:
Vol. 149. no. 3685, pp. 757 - 758
DOI: 10.1126/science.149.3685.757
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Articles

Transformation by Rous Sarcoma Virus: A Requirement for DNA Synthesis

John P. Bader 1

1 Carcinogenesis Studies Branch, National Cancer Institute, Bethesda, Maryland

Transient inhibition of DNA synthesis immediately after infection of cells with Rous sarcoma virus prevents subsequent morphological transformationof the cells. Inhibition of DNA synthesis for an identical period before infection, or later in the course of infection, has only slight effect on transformation. Thus DNA synthesis is a specific requirement in the transformation of cells by Rous sarcoma virus.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)