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Science 13 August 1965:
Vol. 149. no. 3685, pp. 754 - 755
DOI: 10.1126/science.149.3685.754
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Articles

Adenovirus-Associated Defective Virus Particles

Robert W. Atchison 1, Bruce C. Casto 1, and William McD. Hammon 1

1 Department of Epidemiology and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania

Small, DNA-containing particles were separated from preparations of a simian adenovirus. These particles differed antigenically from the adenovirus. Replication of the particles in cell cultures was obtained only when theywere inoculated simultaneously with adenoviruses. This suggests that these adenovirus-associated particles behave as defective viruses.


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