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Science 16 July 1965:
Vol. 149. no. 3681, pp. 310 - 311
DOI: 10.1126/science.149.3681.310
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Articles

Interferon-Like Virus-Inhibitor Induced in Human Leukocytes by Phytohemagglutinin

E. Frederick Wheelock 1

1 Departments of Preventive Medicinev and Medicine, School of Medicine, Western Reserve University, and University Hospitals, Cleveland, Ohio

Phytohemagglutinin, an extract of the kidney bean, Phaseolus vulgaris, induces in human leukocyte cultures an inhibitor of the cytopathic effects of Sindbis virus. The physicochemical and biological properties of this virus-inhibitor are similar to those of interferon induced by Newcastle disease virus, except for an instability at pH 2 and 10 and at 56°C.


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