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Science 9 July 1965:
Vol. 149. no. 3680, pp. 201 - 202
DOI: 10.1126/science.149.3680.201
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Articles

Induced Hypersensitivity to Cold

Hans Selye 1

1 Institute de Médecine et de Chirurgie Experimentales, Université de Montréal, Montreal, Quebec

Extreme hypersensitivity to cold can be induced in the rat by a single subcutaneous injection of carrageenin. In animals so treated, exposure to cold induces necrotizing thrombohemorrhagic lesions in the nose, paws, and tail, accompanied by renal lesions resembling those of the generalized Sanarelli-Shwartzman phenomenon. The same treatment elicits hemorrhagic necroses of transplants of Murphy lymphosarcomas in rats.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Localized "Secondary" Cold Urticaria.
L. M. SOLOMON, H. STRAUSS, and A. LEZNOFF (1966)
Arch Dermatol 94, 156-160
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Science. ISSN 0036-8075 (print), 1095-9203 (online)