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Science 9 July 1965:
Vol. 149. no. 3680, pp. 197 - 199
DOI: 10.1126/science.149.3680.197
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Articles

Serotonin: Synthesis and Release from the Myenteric Plexus of the Mouse Intestine

Michael D. Gershon 1, Anna B. Drakontides 1, and Leonard L. Ross 1

1 Department of Anatomy, Cornell University Medical College,. New York 10021

After injection of its radioactive precursor, 5-hydroxytryptophan, radioactive serotonin was biosynthesized and bound in the myenteric plexus of the mouse intestine. Addition of nonradioactive serotonin to preparations in vitro caused a net release of radioactive serotonin from the plexus. This release appeared to result from activity in the intramural nervous system of the intestine. A neurotransmitter role between sensory and motor neurons in the peristaltic reflex pathway is suggested as a working hypothesis to explain the action of serotonin.


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