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Science 2 July 1965:
Vol. 149. no. 3679, pp. 80 - 82
DOI: 10.1126/science.149.3679.80
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Articles

Alcohol Dehydrogenase in Drosophila melanogaster: Isozymes and Genetic Variants

E. H. Grell 1, K. Bruce Jacobson 1, and J. B. Murphy 1

1 Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee

Alcohol dehydrogenase, in Drosophila melanogaster homozygous for the alleles AdhF or AdhS, is found in three electrophoretically different forms. Adh' differs from Adh5 in that isozymes with faster electrophoretic mobilities are present. In AdhF/AdhS heterozygotes, hybrid isozymes as well as the parental isozymes are present, indicating that the dehydrogenase may exist as a dimer of two polypeptide subunits. The gene, Adh, is located on the second chromosome, with a map position of 50.1 and a cytological position between 34E3 and 35D1.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Simple Gene with a Complex Pattern of Transcription: The Alcohol Dehydrogenase Gene of Drosophila melanogaster.
C. Savakis and M. Ashburner (1985)
Cold Spring Harb Symp Quant Biol 50, 505-514
   Abstract »    PDF »
Assay Systems for the Study of Gene Function: Two assay systems, the syntheses of RNA and of protein, are described; their virtues and drawbacks are discussed.
H. Ursprung, K. D. Smith, W. H. Sofer, and D. T. Sullivan (1968)
Science 160, 1075-1081
   Abstract »    PDF »
Alcohol Dehydrogenase of Drosophila: Interconversion of Isoenzymes.
K. B. Jacobson (1968)
Science 159, 324-325
   Abstract »    PDF »
Electrophoretic Variation in Enzymes.
C. R. Shaw (1965)
Science 149, 936-943
   PDF »


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