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Science 25 June 1965:
Vol. 148. no. 3678, pp. 1734 - 1737
DOI: 10.1126/science.148.3678.1734
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Articles

Hydrogen-Bonded Dimers of Adenine and Uracil Derivatives

Roy M. Hamlin Jr. 1, R. C. Lord 1, and Alexander Rich 1

1 Departments of Chemistry and Biology, and Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge

In concentrated solutions of either 9-ethyladenine or 1-cyclohexyluracil in deuterochloroform, absorption bands in the infrared spectrum demonstrate hydrogen bonding of the adenine and uracil derivatives with themselves. In dilute solutions, there is very little hydrogen bonding. However, when dilute solutions of 9-ethyladenine and 1-cyclohexyluracil are mixed, a series of bands appear which show that these molecules are hydrogen-bonding with each other much more strongly than with themselves. A study of the stoichiometry of this association indicates formation of 1:1 hydrogen-bonded pairs in solution.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Crystal Structure of the 1 : 1 Complex of 5-Fluorouracil and 9-Ethylhypoxanthine.
S.-H. Kim and A. Rich (1967)
Science 158, 1046-1048
   Abstract »    PDF »
Hydrogen Bonding Specificity of Nucleic Acid Purines and Pyrimidines in Solution.
Y. Kyogoku, R. C. Lord, and A. Rich (1966)
Science 154, 518-520
   Abstract »    PDF »


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