Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 28 May 1965:
Vol. 148. no. 3674, pp. 1242 - 1244
DOI: 10.1126/science.148.3674.1242
Prev | Table of Contents | Next

Articles

Functional Studies of Cultured Brain Tissues as Related to "Demyelinative Disorders"

Murray B. Bornstein 1 and Stanley M. Crain 2

1 Laboratory of Cellular Neurophysiology, Department of Neurology, Mt. Sinai Hospital, New York, New York
2 Departments of Anatomy and Neurology, College of Physicians and Surgeons, Columbia University, New York, New York

The serums from animals with experimental allergic encephalomyelitis and humans with multiple sclerosis produce, in addition to demyelination, rapid, reversible alterations in complex, evoked bioelectric (synaptic) responses of cultured cerebral cortex and spinal cord tissues of the mouse. The active factors are dependent on complement and are not present in serums from normal animals and humans.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The pentapeptide QYNAD does not block voltage-gated sodium channels.
T.R. Cummins, M. Renganathan, P.K. Stys, R.I. Herzog, K. Scarfo, R. Horn, S.D. Dib-Hajj, and S.G. Waxman (2003)
Neurology 60, 224-229
   Abstract »    Full Text »    PDF »
Axonal Transection in the Lesions of Multiple Sclerosis.
B. D. Trapp, J. Peterson, R. M. Ransohoff, R. Rudick, S. Mork, and L. Bo (1998)
N. Engl. J. Med. 338, 278-285
   Abstract »    Full Text »    PDF »
Effects of Temperature in Multiple Sclerosis: A Review of the Literature.
K. Syndulko, M. Jafari, A. Woldanski, R. W. Baumhefner, and W. W. Tourtellotte (1996)
Neurorehabil Neural Repair 10, 23-34
   Abstract »    PDF »
Amyotrophic Lateral Sclerosis: Associated Clinical Disorders and Immunological Evaluations.
S. H. Appel, V. Stockton-Appel, S. S. Stewart, and R. H. Kerman (1986)
Arch Neurol 43, 234-238
   Abstract »    PDF »
Studies of Hyperthermia in Optic Neuropathy: Consideration of a Humoral Factor.
P. H. Zweifach (1978)
Arch Ophthalmol 96, 1831-1834
   Abstract »    PDF »
Neuroelectric Blocking Factors in Multiple Sclerosis and Normal Human Sera.
F. J. Seil, A. L. Leiman, and J. M. Kelly III (1976)
Arch Neurol 33, 418-422
   Abstract »    PDF »
Myelination inhibiting and neuroelectric blocking factors in experimental allergic encephalomyelitis.
F. Seil, M. Smith, A. Leiman, and J. Kelly 3rd (1975)
Science 187, 951-953
   Abstract »    PDF »
Leukocyte Sensitivity to Brain Fractions in Neurological Diseases.
E. C. Alvord Jr., P. C. Hsu, and R. Thron (1974)
Arch Neurol 30, 296-299
   Abstract »    PDF »
The Direct Coombs' Test: Its Clinical Significance: Study in a Large University Hospital.
R. F. BOHNEN, J. E. ULTMANN, J. G. GORMAN, M. FARHANGI, and J. SCUDDER (1968)
Ann Intern Med 68, 19-32
   Abstract »    PDF »
Molecular Biology Among the Neurosciences.
F. O. Schmitt (1967)
Arch Neurol 17, 561-572
   Abstract »    PDF »
Multiple Sclerosis: Serum Factor Producing Reversible Alterations in Bioelectric Responses.
J. A. Cerf and G. Carels (1966)
Science 152, 1066-1068
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)