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Science 28 May 1965:
Vol. 148. no. 3674, pp. 1229 - 1231
DOI: 10.1126/science.148.3674.1229
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Articles

Lysis of Pleuropneumonia-like Organisms by Staphylococcal and Streptococcal Toxins

Alan W. Bernheimer 1 and Morton Davidson 2

1 Department of Microbiology
2 Department of Medicine, New York University School of Medicine, New York

Six strains representing three species of Mycoplasma were examined for susceptibility to lysis by staphylococcal and streptococcal toxins. All were sensitive to staphylococcal agr-toxin, two to streptolysin S, and three to streptolysin O. The results support the concept that the limiting membrane of pleuropneumonia-like organisms is basically similar to those of many other cell types and provide additional evidence for the participation of cholesterol in cytolysis induced by streptolysin O.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Structural elements of the cholesterol-dependent cytolysins that are responsible for their cholesterol-sensitive membrane interactions.
C. E. Soltani, E. M. Hotze, A. E. Johnson, and R. K. Tweten (2007)
PNAS 104, 20226-20231
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Ehrlichia chaffeensis and Anaplasma phagocytophilum Lack Genes for Lipid A Biosynthesis and Incorporate Cholesterol for Their Survival.
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Cytolytic Toxins of Bacterial Origin: The nature and properties of cytolytic proteins are discussed with emphasis on staphylococcal agr-toxin.
A. W. Bernheimer (1968)
Science 159, 847-851
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Purified Staphylococcal Alpha Toxin: Effect on Epithelial Ion Transport.
J. J. Rahal Jr., M. E. Plaut, H. Rosen, and L. Weinstein (1967)
Science 155, 1118-1120
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Science. ISSN 0036-8075 (print), 1095-9203 (online)