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Science 9 April 1965:
Vol. 148. no. 3667, pp. 250 - 252
DOI: 10.1126/science.148.3667.250
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Articles

Lesions in the Medial Forebrain Bundle: Delayed Effects on Sensitivity to Electric Shock

John A. Harvey 1 and Carlton E. Lints 2

1 Departments of Psychology and Pharmacology, University of Chicago
2 Department of Psychology, University of Chicago, Chicago, Illinois

Rats with bilateral lesions in the medial forebrain bundle demonstrate both an increased sensitivity to electric shock, as reflected by a lowered jump threshold, and a decrease in the concentration of serotonin in the brain. Both effects of the lesion are characterized by a delayed time of onset and gradual development, which approximates the time required for progressive nerve degeneration in the central nervous system. It is suggested that this behavioral effect of bilateral lesions in the medial forebrain bundle may be due to a central denervation supersensitivity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of long-term corn consumption on brain serotonin and the response to electric shock.
L. Lytle, R. Messing, L Fisher, and L Phebus (1975)
Science 190, 692-694
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Sleep Suppression after Basal Forebrain Lesions in the Cat.
D. J. McGinty and M. B. Sterman (1968)
Science 160, 1253-1255
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Science. ISSN 0036-8075 (print), 1095-9203 (online)