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Science 2 April 1965:
Vol. 148. no. 3666, pp. 86 - 87
DOI: 10.1126/science.148.3666.86
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Articles

Retinoyl Beta-Glucuronic Acid: A Major Metabolite of Vitamin A in Rat Bile

Percy E. Dunagin Jr. 1, E. Harris Meadows Jr. 1, and James Allen Olson 1

1 Department of Biochemistry, University of Florida College of Medicine, Gainesville

The major metabolite in rat bile of injected C14-retinoic acid was purified by ion-exchange and silicic acid chromatography; it has the spectrum of methyl retinoate, releases retinoic acid upon basic hydrolysis or by treatment with beta-glucuronidase, and contains glucuronic acid. The metabolite was characterized by treatment with diazomethane followed by hexamethyl-disilazane, or with periodate followed by semicarbazide, and the products were chromatographed. The metabolite has been tentatively identified as retinoyl beta-glucuronide.


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