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Science 26 March 1965:
Vol. 147. no. 3665, pp. 1583 - 1585
DOI: 10.1126/science.147.3665.1583
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Articles

Noradrenaline Stores in Nerve Terminals of the Spleen: Changes during Hemorrhagic Shock

Annica B. Dahlström 1 and Bengt E. M. Zetterström 1

1 Department of Histology, Karolinska Institute, and Department of Surgery and Research Laboratory, Thoracic Clinic, Karolinska Hospital, Stockholm

In dogs subjected to hemorrhagic shock, a marked decrease in the noradrenaline content of the sympathetic nerve terminals in the normally innervated spleen is revealed by means of a histochemical fluorescence method. Deprivation of the sympathetic impulse-flow to the tissue immediately before the animals are subjected to shock prevents this depletion. The results support the hypothesis that the vasoconstriction which occurs during shock is due to the effect of noradrenaline released locally in the tissues, and not to circulating noradrenaline.


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