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Science 19 March 1965:
Vol. 147. no. 3664, pp. 1462 - 1465
DOI: 10.1126/science.147.3664.1462
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Articles

Structure of a Ribonucleic Acid

Robert W. Holley 1, Jean Apgar 1, George A. Everett 1, James T. Madison 1, Mark Marquisee 1, Susan H. Merrill 1, John Robert Penswick 1, and Ada Zamir 1

1 U.S. Plant, Soil, and Nutrition Laboratory, U.S. Department of Agriculture, and Department of Biochemistry, Cornell University, Ithaca, New York

The complete nucleotide sequence of an alanine transfer RNA, isolated from yeast, has been determined. This is the first nucleic acid for which the structure is known.


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Transfer RNA Crystals Studied by X-Ray Diffraction.
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Single Crystals of Transfer RNA: An X-Ray Diffraction Study.
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The Cytokinins.
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Proton Magnetic Resonance of Transfer RNA.
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Progress in the Total Synthesis of the Gene for ala-tRNA.
H. G. Khorana, H. Buchi, M. H. Caruthers, S. H. Chang, N. K. Gupta, A. Kumar, E. Ohtsuka, V. Sgaramella, and H. Weber (1968)
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Nucleotide Sequence of KB Cell 5S RNA.
B. G. Forget and S. M. Weissman (1967)
Science 158, 1695-1699
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Chemical Modification of Yeast Alanine-tRNA with a Radioactive Carbodiimide.
S. W. Brostoff and V. M. Ingram (1967)
Science 158, 666-669
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Yeast Transfer RNA: A Small-Angle X-Ray Study.
J. A. Lake and W. W. Beeman (1967)
Science 156, 1371-1373
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Cytokinin Activity: Localization in Transfer RNA Preparations.
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Nucleotide Sequence of a Yeast Tyrosine Transfer RNA.
J. T. Madison, G. A. Everett, and H. Kung (1966)
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RNA Composition and Base Pairing.
W. Traub and D. Elson (1966)
Science 153, 178-180
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Molecular Mechanisms of Antibiotic Action.
W. CARTER and K. S. MCCARTY (1966)
Ann Intern Med 64, 1087-1113
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The Genetic Code--Yesterday, Today, and Tomorrow.
F. H. C. Crick (1966)
Cold Spring Harb Symp Quant Biol 31, 3-9
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The RNA Code and Protein Synthesis.
M. Nirenberg, T. Caskey, R. Marshall, R. Brimacombe, D. Kellogg, B. Doctor, D. Hatfield, J. Levin, F. Rottman, S. Pestka, et al. (1966)
Cold Spring Harb Symp Quant Biol 31, 11-24
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sRNA Specificity for Codon Recognition as Studied by the Ribosomal Binding Technique.
D. Soll, J. Cherayil, D. S. Jones, R. D. Faulkner, A. Hampel, R. M. Bock, and H. G. Khorana (1966)
Cold Spring Harb Symp Quant Biol 31, 51-61
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On the Nucleotide Sequence of Yeast Tyrosine Transfer RNA.
J. T. Madison, G. A. Everett, and H. K. Kung (1966)
Cold Spring Harb Symp Quant Biol 31, 409-416
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Serine Specific Transfer Ribonucleic Acids. XIV. Comparison of Nucleotide Sequences and Secondary Structure Models.
H. G. Zachau, D. Dutting, H. Feldmann, F. Melchers, and W. Karau (1966)
Cold Spring Harb Symp Quant Biol 31, 417-424
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Nucleotide Sequence Studies on Yeast Phenylalanine sRNA.
U. L. RajBhandary, A. Stuart, R. D. Faulkner, S. H. Chang, and H. G. Khorana (1966)
Cold Spring Harb Symp Quant Biol 31, 425-434
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Degenerate Transfer RNAs from Brewer's Yeast.
P. L. Bergquist (1966)
Cold Spring Harb Symp Quant Biol 31, 435-447
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Disulfide Bonds in sRNA.
M. N. Lipsett (1966)
Cold Spring Harb Symp Quant Biol 31, 449-455
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Coding Properties of Methyl-Deficient Phenylalanine Transfer RNA.
U. Z. Littauer, M. Revel, and R. Stern (1966)
Cold Spring Harb Symp Quant Biol 31, 501-514
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Studies on the Species Specificity of Yeast and E. coli Tyrosine tRNAs.
B. P. Doctor, J. E. Loebel, and D. A. Kellogg (1966)
Cold Spring Harb Symp Quant Biol 31, 543-548
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Modification of sRNA and Regulation of Protein Synthesis.
N. Sueoka, T. Kano-Sueoka, and W. J. Gartland (1966)
Cold Spring Harb Symp Quant Biol 31, 571-580
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Structure of an Alanine Transfer Ribonucleic Acid.
R. W. Holley (1965)
JAMA 194, 868-871
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Nucleotide Sequence of a Gene: First Complete Specification.
T. M. Sonneborn (1965)
Science 148, 1410
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