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Science 19 March 1965:
Vol. 147. no. 3664, pp. 1443 - 1445
DOI: 10.1126/science.147.3664.1443
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Articles

Uracil Mustard: A Potent Inducer of Lung Tumors in Mice

C. W. Abell 1, H. L. Falk 1, M. B. Shimkin 1, E. K. Weisburger 1, J. H. Weisburger 1, and N. Gubareff 2

1 National Cancer Institute, National Institutes of Health, Bethesda, Maryland
2 Scientific Associates, Inc., St. Louis, Missouri

Uracil mustard, injected intraperitoneally, increased the incidence and average number of pulmonary tumors in A/J mice. In comparison to a typical alkylating agent, nitrogen mustard, or to urethan, uracil mustard (on a molar basis) was considerably more carcinogenic.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Mice with Focal Pulmonary Fibrosis Caused by Monocrotaline are Insensitive to Urethane Induction of Lung Tumorigenesis.
K. Yasuhara, K. Mitsumori, T. Shimo, H. Onodera, M. Takahashi, and Y. Hayashi (1997)
Toxicol Pathol 25, 574-581
   Abstract »    PDF »
Strain a Mouse Lung Tumor Bioassay.
G. D. Stoner and M. B. Shimkin (1982)
International Journal of Toxicology 1, 145-169
   Abstract »    PDF »


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