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Science 12 March 1965:
Vol. 147. no. 3663, pp. 1305 - 1307
DOI: 10.1126/science.147.3663.1305
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Articles

Intermolecular Forces in Association of Purines with Polybenzenoid Hydrocarbons

Bernard Pullman 1, Pierre Claverie 1, and Jacqueline Caillet 1

1 Université de Paris, institut de Biologie Physico-Chimique, 13, rue Pierre Curie, Paris 5

The interactions in solution between purine or pyrimidine bases and polybenzenoid aromatic hydrocarbons probably consist in a vertical, stacking-type physical association. By molecular orbital calculations the role of the Van der Waals-London intermolecular forces in these interactions is determined. The electrostatic dipole-dipole forces are negligible, the polarization (or induction) dipole-induced dipole forces are contributory, but most important are the dispersion (or fluctuation) forces. This loose, physical type of interaction should not show any specificity with respect to the carcinogenic activity of the hydrocarbons.

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Science. ISSN 0036-8075 (print), 1095-9203 (online)